Blended insights from the ReAttach M.I.S.T. and Emotional Symptom Regulation Model (ESRM).
Trefwoorden:
ReAttach, M..I.S.T, W.A.R.A., Forgive and Forget Hood, Functional Neurological Disorder, Emotional Symptom Regulation Model (ESRM)Samenvatting
Objective:Recent extensive digital phenotyping studies in Functional Neurological Disorder (FND) have uncovered seven unique clusters of emotional states, which challenge the conventional binary view of distress and resilience [1]. The current study intends to create a clinical framework driven by theory and aimed at generating hypotheses that connect these emotional state clusters to the transdiagnostic mechanisms of ReAttach therapy and its diagnostic interview, the Mapping the Individual State of Mind (M.I.S.T.) [3,7].
Method:The researchers performed a conceptual integration of data on digital emotional phenotyping in FND [1] with both empirical and theoretical literature regarding ReAttach therapy [3], W.A.R.A. (Wiring Affect with ReAttach) [4–6,16], and the M.I.S.T. framework [7]. This integration concentrated on arousal regulation, sensory integration, affect wiring, modification of cognitive biases, and processing of social rewards. Evidence from pilot studies, small-scale randomized trials, and protocol-based investigations was used to support the proposed clinical linkages [4,5,16].
Results: The study result has been structured as a clinical mapping model that connects the seven emotional state clusters in FND (Distress, Shutdown, Activation, Anger, Social Isolation, Resilience, and Ambivalence) to specific transdiagnostic intervention strategies. Initial findings from pilot studies and small randomized comparisons indicate that ReAttach-based interventions may decrease the intensity and duration of negative affect, enhance emotional regulation, and improve therapeutic engagement in patients who have difficulties with standard top-down approaches [3–6]. Specifically, W.A.R.A. has shown to be more effective in the short term for reducing negative affect compared to distraction techniques in randomized pilot studies, with positive effects seen in both in-person and remote delivery settings [5,16]. Further observational and protocol-based studies suggest enhancements in emotional regulation, perceived control, and resilience across a variety of psychobiosocial conditions [8,9,31].
Conclusions:The study does not assert clinical efficacy but offers a theoretically sound and neurobiologically plausible framework for customizing psychological interventions in FND based on an individual's mental state. The combination of emotional state phenotyping with the M.I.S.T. framework presents a structured hypothesis foundation for upcoming controlled trials and precision-oriented treatment development in FND and other related psychobiosocial conditions [27,29].
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Copyright (c) 2025 Steven Painter, Dr. Paula Zeestraten-Bartholomeus, Mohadeseh Bita, Prof. Dr. Aida Mehrad (Author)

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